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93.859 Biomedical Research and Research Training




Section 301 and Title IV of the Public Health Service Act, as amended.
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The National Institute of General Medical Sciences (NIGMS) supports basic research that increases understanding of biological processes and lays the foundation for advances in disease diagnosis, treatment and prevention. NIGMS-funded scientists investigate how living systems work at a range of levels, from molecules and cells to tissues, whole organisms and populations. The Institute also supports research in certain clinical areas, primarily those that affect multiple organ systems. To assure the vitality and continued productivity of the research enterprise, NIGMS provides leadership in training the next generation of scientists, in enhancing the diversity of the scientific workforce, and in developing research capacities throughout the country.


Project Grants.
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The research project grant is awarded to an eligible institution on behalf of a principal investigator to support a discrete project or group of related projects representing the investigator's area of interest and competence. Funds are used for reasonable costs of the research activity, as well as for salaries, equipment, supplies, travel, and other related expenses. National Research Service Awards are made directly to individuals for postdoctoral research training. In addition, grants are made to institutions to enable them to make National Research Service Awards to individuals selected by them for predoctoral and postdoctoral training. Responsibilities of grantees and restrictions on use of funds are set forth in the Public Health Service policy statement on grants for research projects, which is available on request from the Division of Extramural Outreach and Information Resources, NIH, Bethesda, MD 20892. SBIR Phase I grants (of approximately 6 months' duration) are to establish the scientific and technical merit and feasibility of a proposed research effort that may lead to a commercial product or process. Phase II grants are for the continuation of research initiated in Phase I that is likely to result in commercial products or processes. Only Phase I awardees are eligible to receive Phase II support. STTR Phase I grants (normally of 1 year's duration) are to determine the scientific, technical, and commercial merit and feasibility of proposed cooperative effort that has potential for commercial application. Phase II funding is based on the results of research initiated in Phase I.


Applicant Eligibility:   NIGMS trainees must be U.S. citizens, non-citizen nationals or permanent residents.
Beneficiary Eligibility:   Any nonprofit or for-profit organization, company or institution engaged in biomedical research.
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Pre-application Coordination:   Not applicable. This program is excluded from coverage under E.O. 12372.

Application Procedure:   This program is excluded from coverage under 2 CFR 200, Uniform Administrative Requirements, Cost Principles, and Audit Requirements for Federal Awards. NIH announces availability of funds for grant programs by issuing funding opportunity announcements in the NIH Guide for Grants and Contracts ( and on ( Application packages must be downloaded from and the majority must be submitted through This program is subject to the provisions of 45 CFR, Part 92 for state and local governments and 45 CFR, Part 72 for other organizations, as appropriate.

Award Procedure:   All accepted applications for project grants, SBIR/STTR grants, and institutional National Research Service Awards are reviewed for scientific merit by an appropriate initial review group and by a national advisory council. (NRSA applications for the support of individual fellows are not reviewed by the council.) All approved applications compete for available funds on the basis of scientific merit and program emphasis.

Deadlines:   Contact the headquarters or regional office, as appropriate, for application deadlines.

Range of Approval/Disapproval Time:   Project Grants: About 9 months. NRSA: (institutional) 9-12 months, (individual) 6 months. SBIR/STTR: About 7-1/2 months.

Appeals:   A principal investigator (P.I.) may question the substantive or procedural aspects of the review of his/her application by communicating with the staff of the Institute. A description of the NIH Peer Review Appeal procedures is available on the NIH Web site at

Renewals:   Renewal grants are generally made prior to the expiration of any current award.


Formula and Matching Requirements:   This program has no statutory formula or matching requirements.

Length and Time Phasing of Assistance:   All awards are made for at least 1 year, with additional support (up to 4 more years) depending on the recommendation of the scientific review group, the national advisory council, successful annual performance, and availability of funds. SBIR: Normally, Phase I awards are for 6 months; normally, Phase II awards are for 2 years. STTR: Normally, Phase I awards are for 1 year; normally, Phase II awards are for 2 years.


Reports:   Annual progress and selected financial status reports for continuing projects and final reports on all projects upon conclusion are required. Recipients of National Research Service Awards are required to file termination reports to ascertain compliance with the service and payback provisions.

Audits:   In accordance with the provisions of OMB Circular No. A-133 (Revised, June 24, 1997), "Audits of States, Local Governments, and Non-Profit Organizations," nonfederal entities that expend financial assistance of $300,000 or more in Federal awards will have a single or a program-specific audit conducted for that year. Nonfederal entities that expend less than $300,000 a year in Federal awards are exempt from Federal audit requirements for that year, except as noted in Circular No. A-133. In addition, grants and cooperative agreements are subject to inspection and audits by DHHS and other Federal government officials.

Records:   Expenditures and other financial records must be retained for 3 years from the day on which the grantee submits the last financial status report for the report period.


Account Identification:   75-0897-0-1-552.

Obligations:   (Project Grants) FY 15 $2,267,199,021; FY 16 est $2,405,188,000; and FY 17 est $2,407,077,000

Range and Average of Financial Assistance:  
$20,000 to $10,000,000.

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Not Applicable.


42 CFR 52; 45 CFR 66; 45 CFR 74; 45 CFR 92; NIH Extramural Programs brochure; miscellaneous program literature from Headquarters Office. Grants will be available under the authority of and administered in accordance with the PHS Grants Policy Statement and Federal regulations at 42 CFR 52 and 42 USC 241; Omnibus Solicitation of the Public Health Service for Small Business Innovation Research (SBIR) Grant and Cooperative Agreement Applications. Omnibus Solicitation of the National Institutes of Health for Small Business Technology Transfer (STTR) Grant Applications.


Regional or Local Office:   Not applicable.

Headquarters Office:   Susan J. Athey 45 Center Drive MSC6200, Bethesda, Maryland 20892 Email: Phone: (301) 496-7301 Fax: (301) 402-0224

Web Site Address:


Fiscal Year 2015: No Current Data Available Fiscal Year 2016: No Current Data Available Fiscal Year 2017: No Current Data Available


For an overview of NIGMS grant application and review, including funding policy, see For more information about NIGMS, visit

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